Principal Manufacturing Systems Engineer

Company: Amgen
Location: Thousand Oaks
Posted on: July 17, 2025

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Manufacturing Systems Engineer What you will do and what we expect of you Lets do this. Lets change the world. In this vital role you will: Duties: Own and shape the design and technology of the Manufacturing Information & Technology ecosystem by leading the execution of IS and Automation projects with appropriate portfolio planning, resource and risk management, and financial management for the portfolio; Review engineering project requirements, schedule, and budget; Prepare industrial automation projects detailed estimate assessment; Submit project deliverables, ensuring adherence to quality standards; Prepare project status reports by collecting, analyzing, and summarizing information and trends; Perform risk assessments to develop response strategies; Initiate, review, or approve modifications to project plans; Schedule and facilitate meetings related to information technology projects; Develop and manage annual budgets for information technology projects; Perform cross system analysis, feasibility analysis, scope projects, prioritize deliverables, and recommend optimal solutions; Manage project proposal creation activities, staffing analysis, and solutioning activities to prepare for the solution delivery of the proposal; and Prepare a detailed schedule for automation scope and provide inputs to overall project schedule while tracking project deliverables for assigned scope. May Telecommute. Position requires up to 20% travel to various unanticipated worksites nationally and internationally Requirements: Bachelors degree (or foreign equivalent) in Electronics Engineering, Computer Science, or related field and 7 years of experience in the following: 1. Product platforms such as Data Historian (OSI PI), MES (Werum), and Automation and Control Systems like DeltaV and Rockwell; 2. Methods and technologies to support Manufacturing Data integrations such as SQL, Web Services, messaging, and data mapping; 3. Translating strategic opportunities and emerging technology solutions into executable plans allied to business standards; 4. Good automated manufacturing practice (GAMP) software development lifecycle, ANSI/ISA-S88, and S95 industry standards and methodologies to establish Process Control System (PCS) and Manufacturing Execution System (MES) implementation; 5. Industry standards for software development life cycle methodologies and 21 CFR Part 11; and 6. Pharmaceutical commissioning and validation. Contact: Interested candidates please apply via https://careers.amgen.com/en/search-jobs and search for job R-219261. Rate of Pay: The annual salary range for this position in the U.S. is $159,910.00 $186,712.00 per year. Also, this position offers stock, retirement, medical, life and disability insurance and eligibility for an annual bonus or for sales roles, other incentive compensation. For more details visit https://careers.amgen.com/life-at-amgen/benefits/ What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Keywords: Amgen, Santa Ana , Principal Manufacturing Systems Engineer, Engineering , Thousand Oaks, California